An efficient synthesis of polysubstituted pyrroles via copper-catalyzed coupling of oxime acetates with dialkyl acetylenedicarboxylates under aerobic conditions.

نویسندگان

  • Xiaodong Tang
  • Liangbin Huang
  • Chaorong Qi
  • Wanqing Wu
  • Huanfeng Jiang
چکیده

A Cu-catalyzed [3+2]-type condensation reaction of oxime acetates and dialkyl acetylenedicarboxylates that provides highly substituted pyrroles under aerobic conditions is described. The newly formed pyrroles are easily employed for further transformations to prepare pyrrolo[2,1-a]isoquinoline skeletons.

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عنوان ژورنال:
  • Chemical communications

دوره 49 83  شماره 

صفحات  -

تاریخ انتشار 2013